The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may possibly result in an increase in methadone plasma concentrations, which could induce probably fatal respiratory despair. Moreover, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also cause an in